NCT06721455Recruiting

Modeling Blood Management and Hemolytic Risk in Pediatric Heart Surgery

Boston Children's Hospital

Start Date

8/1/2025

Completion Date

12/31/2026

Summary

This study aims to learn more about blood management in children undergoing heart surgery, such as the right amounts, and the best blood products, to administer. It also aims to develop a mathematical model that may help researchers better predict and treat patients who need blood transfusions during heart surgery.

Eligibility Criteria

Age Range: No minimum to 17 years

Inclusion Criteria: * pediatric patients under 18 years of age undergoing cardiac surgery with clear prime on cardio-pulmonary bypass (CPB) at Boston Children's Hospital (BCH). Exclusion Criteria: * patients with known hemolytic disorders, patients on nitric oxide preoperatively, and patients found to have abnormal coagulation on routine preoperative assessment. Patients receiving heparin, American Society of Anesthesia (ASA) status, apixaban, warfarin, or bivalirudin held appropriately (i.e. for elective surgery) will not be excluded

Interventions

OTHER

blood sampling

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Conditions

Heart SurgeryBlood TransfusionHemolysis

Locations

Boston Children's Hospital

Boston, Massachusetts 02115

United States