NCT06727578NARecruiting

Pleural Irrigation With a Novel Devise.

Beth Israel Deaconess Medical Center

Start Date

5/25/2025

Completion Date

7/31/2026

Summary

Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion * Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion Exclusion Criteria: * Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy) * Post-procedural empyema or complicated parapneumonic effusion

Interventions

DEVICE

of intrapleural saline irrigation with CLR irrigator

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Conditions

Pleural Effusion Disorder

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts 02215

United States