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NCT06743659NARecruiting

Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

Brigham and Women's Hospital

Start Date

4/1/2025

Completion Date

12/31/2027

Summary

The goal of this clinical trial is to learn if a computer alert can aid clinicians in identifying patients with a genetic type of high cholesterol, called Familial Hypercholesterolemia. The main question it aims to answer is whether the computer alert increases recognition of this high cholesterol disorder.

Detailed Description

FH-ALERT is a single-center, time-series trial of a patient- and provider-facing EPIC BPA (alert-based CDS tool) to increase diagnosis, LDL-C lowering, and guideline-based therapy of outpatients with presentations consistent with FH. For the first 6 months, the BPA will run in "silent mode", identifying patients with presentations consistent with FH, but not alerting the clinician of record. Following this initial "pre-alert" 6-month period, the BPA will switch to "alert mode" for 18 months, which will provide the on-screen notification to the clinician of record. In other words, consecutive outpatients with presentations consistent with FH will be enrolled over two years: "pre-alert" (silent mode) for 6 months and "alert mode" for 18 months.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * ≥ 18 years old * seen in the BWH Endocrinology, Cardiovascular Medicine, and Primary Care Clinics * Dutch Lipid Clinic Network score of at least 3 points Exclusion Criteria: * a Familial Hypercholesterolemia diagnosis already documented in the EHR medical history, visit history, or problem list

Interventions

DEVICE

Alert-based computerized decision support

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Conditions

Familial Hypercholesterolaemia

Locations

Brigham and Women's Hospital

Boston, Massachusetts 02115

United States