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NCT06747351PHASE3Recruiting

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Takeda

Start Date

5/6/2025

Completion Date

6/25/2028

Summary

The main aim of this study is to evaluate the pharmacokinetic (PK) comparability between TAK-881 and HYQVIA subcutaneous (SC) administration for maintenance therapy of CIDP. The participants who are already receiving intravenous immunoglobulin G (IGIV), conventional subcutaneous intravenous immunoglobulin G (cIGSC), or HYQVIA will be treated with the same dose equivalent as their prior IG treatment with HYQVIA for 20 weeks followed by TAK-881 for 24 weeks. Participants will need to visit the clinic every 3 or 4 weeks until they enter the extension phase. In the extension phase, home infusions are allowed, and visits will occur between every 12 weeks and 24 weeks.

Detailed Description

The study includes a screening phase, a ramp-up phase (if needed), a HYQVIA treatment phase, a TAK-881 treatment phase, and an extension phase. Participants who have been receiving cIGSC or IGIV prior to the study will enter a HYQVIA ramp-up phase, starting 1 to 2 weeks after their last pre-study cIGSC or IGIV dose. Participants already on HYQVIA at the time of screening will proceed directly to the treatment phase. After the TAK-881 dosing phase, participants will move on to the TAK-881 extension phase, with the preference for subsequent infusions in the extension phase to be administered by the participant or caregiver at home.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria * Participant is willing and able to understand and fully comply with trial procedures and requirements, in the opinion of the investigator. * Participant has provided informed consent (that is, in writing, documented via a signed and dated informed consent Form \[ICF\]) and any required privacy authorization before the initiation of any trial procedures. * Participant has a documented diagnosis of CIDP or possible CIDP, as confirmed by a neurologist specializing/experienced in neuromuscular diseases and consistent with the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) 2021 criteria. * Participant has responded to IgG treatment in the past (documented partial or complete resolution of neurological symptoms and deficits). * Participant is on a stable, pretrial treatment with IGIV, cIGSC, or HYQVIA (also known as TAK-771 in Japan) within the dose range equivalent to a cumulative monthly IgG dose of 0.4 to 2.4 grams per kilogram (g/kg) body weight (BW) (inclusive) administered for at least 12 weeks before screening. The dosing interval of IGIV treatment must be between 2 and 6 weeks (inclusive). The dosing interval must be weekly or biweekly for cIGSC dosing and less than or equal (\<=) to 6 weeks for HYQVIA dosing. Prior to screening, variations in the dosing interval of up to +-7 days or monthly dose amount of up to +-20 percentage (%) between the participant's pretrial IgG infusions are acceptable. * Participant has an INCAT disability score between 0 and 7 (inclusive). Participants will be eligible if one of the below eligibility criteria are met: 1. Screening INCAT disability score of between 3 and 7 inclusive. 2. Screening INCAT disability score of 2 (both points are from lower extremities). 3. Screening INCAT disability score of 2 (both points are not from lower extremities) AND has at least a score of 2 or greater documented in the medical record before screening. If a score was greater than 2 documented in the medical record before screening at least 2 points must be from lower extremities. 4. Screening INCAT disability score of 0 or 1 AND has at least a score of 2 or greater (both from lower extremities) documented in the medical record before screening, at least 2 points must be from lower extremities. * If a participant has the potential to become pregnant, they must have a negative pregnancy test at screening and agree to employ a highly effective contraceptive measure throughout the course of the trial and for at least 30 days after the last administration of the investigational medical product (IMP). Exclusion Criteria * Participant with documented diagnosis of focal, multifocal, distal, or sensory CIDP, or possible focal, multifocal, distal, or sensory CIDP per the EFNS/PNS 2021 criteria. * Participant has any neuropathy of other causes, including: 1. Hereditary demyelinating neuropathies, such as hereditary sensory and motor neuropathy (HSMN), Charcot-Marie-Tooth (CMT) disease, and hereditary sensory and autonomic neuropathies (HSANs). 2. Neuropathies secondary to infections, disorders, or systemic diseases such as Borrelia burgdorferi infection (Lyme disease), diphtheria, systemic lupus erythematosus, POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, osteosclerotic myeloma, diabetic and non-diabetic lumbosacral radiculoplexus neuropathy, lymphoma, amyloidosis. 3. Multifocal motor neuropathy (MMN). 4. Drug, biologic, chemotherapy, or toxin-induced peripheral neuropathy. * Participant has any chronic or debilitating disease, or central nervous disorder that causes neurological symptoms or which may interfere with assessment of CIDP or outcome measures, including (but not limited to) multiple sclerosis, arthritis, stroke, Parkinson's disease, and diabetic peripheral neuropathy. Note: Participants with clinically diagnosed diabetes mellitus who do not have diabetic peripheral neuropathy and who have adequate glycemic control with hemoglobin A1c \[HbA1c\] level of less than (\<) 7.5% at screening will be eligible for the trial, provided the electrodiagnostic criteria are consistent with the diagnosis of CIDP or possible CIDP consistent with the EFNS/PNS 2021 criteria and the participant agrees to maintain adequate glycemic control. * Participant is required to take or has taken immunomodulatory/immunosuppressive agents (except IGIV, cIGSC, or fIGSC) that include but are not limited to specific complement inhibitors, rituximab, neonatal FC receptor inhibitors (e.g. efgartigimod), and chemotherapeutic drugs, within 6 months of screening. * Participant is required to take or has taken long-term systemic corticosteroids defined as dosages greater than (\>) 20 milligrams per day (mg/day) prednisone-equivalent for \>30 days within 3 months of screening. Note: Participants using short-pulse dose corticosteroid course and oral daily corticosteroids \<= 20 mg/day prednisone-equivalent are allowed. * Participant has undergone plasma exchange within 3 months before screening. * Participant has immunoglobulin M (IgM) paraproteinemia, including IgM monoclonal gammopathy with a high titer of antibody to myelin-associated glycoprotein. * Participant has immunoglobulin A (IgA) deficiency (IgA \<0.07 grams per liter \[g/L\]) associated with known anti-IgA antibodies and a history of hypersensitivity to human immunoglobulin treatment. * Participant has a condition(s) which could alter protein catabolism and/or IgG use (for example \[eg.\] protein losing enteropathies, and nephrotic syndrome). * Participant has a history or clinical manifestations of chronic kidney disease, or glomerular filtration rate of \<30 milliliters per minute per 1.73 square meter (mL/min/1.73 m\^2) estimated based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at the time of screening. * Participant has a history of malignancy with less than 2 years of complete remission before screening, or active malignancy requiring chemotherapy and/or radiotherapy. Note: Participants with adequately treated basal cell or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, or stable prostate cancer not requiring treatment are eligible. * Participant has congestive heart failure (New York Heart Association class III/IV), unstable angina, unstable cardiac arrhythmias, or uncontrolled hypertension (defined as diastolic blood pressure \>100 millimeters of mercury (mm Hg) and/or systolic blood pressure \>160 mm Hg during the screening epoch confirmed on 2 measures \>30 minutes apart). * Participant has an acquired or inherited thrombophilic disorder, such as protein C deficiency, protein S deficiency, antithrombin deficiency, and primary antiphospholipid antibody syndrome. * Participant has a history of deep vein thrombosis or arterial thromboembolic events (eg, cerebrovascular accident, pulmonary embolism) within 12 months before screening. * Participant has any medical condition, laboratory finding, or physical examination finding that precludes participation or with clinical evidence of any significant acute or chronic disease that, in the opinion of the investigator, may interfere with successful completion of the trial or place the participant at undue medical risk. * Participant has a known history of hypersensitivity or persistent reactions (urticaria, breathing difficulty, severe hypotension, or anaphylaxis) following IGIV, IGSC, and/or immune serum globulin infusions. * Participant has a known systemic hypersensitivity to any of the excipients of TAK-881/HYQVIA in accordance with the Investigator's Brochure (IB)/package insert/Summary of Product Characteristics (SmPC). * Participant has a known systemic hypersensitivity to hyaluronidase or rHuPH20. * Participant has a known history of positive result for or is positive at screening for one or more of the following: hepatitis B surface antigen (HBsAg), polymerase chain reaction (PCR) for hepatitis C virus (HCV), PCR for Human Immunodeficiency Virus (HIV) Type 1 and Type 2. Note: Cured participants with a history of hepatitis C infection who have a negative PCR test at screening are eligible. * Participant has clinically significant anemia that precludes repeated blood sampling during the trial, or hemoglobin level of \<10.0 grams per deciliter (g/dL) at the time of screening. * Participant has any of the following laboratory values at screening: 1. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \>2.5\*upper limit of normal (ULN). 2. Platelet count \<100,000 cells per microliter (cells/µL). 3. Absolute neutrophil count \<1000 cells/µL. * If female, the participant is pregnant or lactating at the time of screening. * Participant has participated in another clinical trial involving an IMP or investigational device within 12 weeks or 5 half-lives, whichever is longer, before enrollment (except for participants rolling over from the Japan study TAK-771-3002) or is scheduled to participate in another clinical trial involving an IMP or investigational device during the course of this trial. * Participant is a trial site employee, an immediate family member (eg, spouse, parent, child, sibling), or is in a dependent relationship with a trial site employee who is involved in conduct of this trial or may consent under duress.

Interventions

BIOLOGICAL

TAK-881

BIOLOGICAL

HYQVIA

DEVICE

SC Investigational Needle Sets

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Conditions

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Locations

HonorHealth Neurology

Scottsdale, Arizona 85251

United States

Stanford Neuroscience Health Center

Palo Alto, California 94304

United States

Yale University School of Medicine

New Haven, Connecticut 06510

United States

Neurology Associates

Maitland, Florida 32751

United States

Knight Neurology

Rockledge, Florida 32955

United States

The Washington University

St Louis, Missouri 63130

United States

NYU Langone Health

New York, New York 10016

United States

University of North Carolina (UNC)

Chapel Hill, North Carolina 27599

United States

Duke University Hospital

Durham, North Carolina 27710

United States

Raleigh Neurology Associates

Raleigh, North Carolina 27607

United States

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina 27157

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

Oregon Health & Science University (OHSU) - Nephrology and Hypertension Clinic - Marquam Hill

Portland, Oregon 97239

United States

Neurology Rare Disease Center

Denton, Texas 76208

United States

The University of Vermont Medical Center

Burlington, Vermont 05401

United States

BCN Research, LLC

Greenfield, Wisconsin 53228

United States

INECO

Rosario, Santa Fe Province 2000

Argentina

Instituto Argentino de Investigacion Neurologica (IADIN)

Buenos Aires, C1015ABR

Argentina

Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05

Czechia

Copenhagen University Hospital

Copenhagen, Capital Region 2100d

Denmark

Aarhus Universitetshospital

Aarhus, Central Jutland 8200

Denmark

Universitätsklinikum Mannheim GmbH

Mannheim, Baden-Wurttemberg 68167

Germany

University of Ulm

Ulm, Baden-Wurttemberg 89081

Germany

Universitaetsklinikum Giessen und Marburg GmbH Standort Marburg

Marburg, Hesse 35043

Germany

Medizinische Hochschule Hannover

Hanover, Lower Saxony 30625

Germany

Charite - Universitatsmedizin Berlin

Berlin, 12203

Germany

Attikon University General Hospital

Athens, Attica 12462

Greece

University General Hospital of Patras

Patras, Peloponnese 26504

Greece

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele

Milan, Lombardy 20132

Italy

IRCCS Istituto Clinico Humanitas

Rozzano, Milano, Lombardia 20089

Italy

Azienda Ospedaliero - Universitaria San Luigi Gonzaga

Orbassano, Torino, Piemonte 10043

Italy

ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia

Brescia, 25123

Italy

Ospedale San Martino

Genova, 16132

Italy

Az Ospedaliera Universitaria Policlinico G Martino

Messina, 98125

Italy

Fondazione Istituto Neurologico Casimiro Mondino

Pavia, 27100

Italy

Azienda Ospedaliero Universitaria Pisana

Pisa, 56126

Italy

Azienda Ospedaliera Universitaria Policlinico Tor Vergata

Rome, 00133

Italy

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital

Nagoya, Aichi-ken 455-8530

Japan

Kumamoto University Hospital

Kumamoto, Kumamoto 860-8556

Japan

Tohoku Medical and Pharmaceutical University Hospital

Sendai, Miyagi 981-8558

Japan

Nara Medical University Hospital

Kashihara, Nara 634-8522

Japan

Higashimatsuyama Municipal Hospital

Higashi-Matsuyama, Saitama 355-0005

Japan

Shiga University of Medical Science Hospital

Ōtsu, Shiga 520-2192

Japan

Tokushima University Hospital

Tokushima, Tokuchima 770-8503

Japan

Juntendo University Hospital

Bunkyo-ku, Tokyo 113-8431

Japan

Oddzial Kliniczny Neurologii

Krakow, Lesser Poland Voivodeship 30-688

Poland

Clinirem Sp zo.o.

Lublin, Lublin Voivodeship 20-064

Poland

Warszawski Uniwersytet Medyczny

Warsaw, Masovian Voivodeship 02-097

Poland

Copernicus Podmiot Leczniczy

Gdansk, Pomeranian Voivodeship 80-462

Poland

Hospital de La Santa Creu I San Pau

Barcelona, 08041

Spain

Hospital Universitari i Politecnic La Fe

Valencia, 46026

Spain

Sahlgrenska Universitetssjukhuset

Gothenburg, Västra Götaland County 41345

Sweden