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NCT06747871NARecruiting

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Duke University

Start Date

4/15/2025

Completion Date

7/30/2027

Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: * Aged 21+ years who smoke cigarettes daily * Chronic non-cancer musculoskeletal pain secondary to structural changes (e.g., low back pain, osteoarthritis) * Have received stable office-based buprenorphine treatment for opioid use disorder for at least 30 days * Self-report smoking at least 10 cigarettes/day * Expired breath carbon monoxide (CO) level \>8 ppm * Have a smartphone capable of running software for ecological momentary assessment * Open to exploring the possibility of quitting smoking Exclusion Criteria: * Pain specifically due to cancer * Other significant health problems * Major surgery within the past 6 months or planned surgery within the timeframe of the study * Current disability litigation * Use of electronic cigarettes or other non-cigarette tobacco products \> 9 of the past 30 days * Current use of nicotine replacement therapy or other cessation treatment * Current daily or near-daily cannabis use * History of psychotic disorder * Acute suicidality or current unstable psychiatric disorder * Positive pregnancy test * Actively seeking smoking cessation treatment

Interventions

BEHAVIORAL

Very Low Nicotine Cigarettes (VLNC)

BEHAVIORAL

Normal Nicotine Cigarettes (NNC)

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Conditions

Chronic PainTobacco UseOpioid Substitution Treatment

Locations

North Pavilion

Durham, North Carolina 27705

United States