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NCT06772675NARecruiting

Vancomycin Reduction Practices (VRP) in the NICU

Children's Hospital of Philadelphia

Start Date

6/2/2025

Completion Date

9/1/2027

Summary

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Level III NICU * Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN) * Recruited by study team Exclusion Criteria: * Site not recruited for the study

Interventions

BEHAVIORAL

External Facilitation

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Conditions

Antibiotic StewardshipNeonatal Sepsis, Late-OnsetVancomycin

Locations

Kaiser Permanente Modesto Medical Center

Modesto, California 95356

United States

Kaiser Permanente East Bay - Oakland Medical Center

Oakland, California 94611

United States

Kaiser Permanente Roseville Medical Center

Roseville, California 95661

United States

Kaiser Permanente San Francisco Medical Center

San Francisco, California 94115

United States

Kaiser Permanente San Leandro Medical Center

San Leandro, California 94577

United States

Kaiser Permanente Santa Clara Medical Center

Santa Clara, California 95051

United States

Kaiser Permanente Walnut Creek Medical Center

Walnut Creek, California 94596

United States

Medical Center of Princeton

Plainsboro, New Jersey 08536

United States

Virtua Voorhees

Voorhees Township, New Jersey 08043

United States

Lancaster General Hospital

Lancaster, Pennsylvania 17602

United States

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Pennsylvania Hospital

Philadelphia, Pennsylvania 19107

United States

Chester County Hospital

West Chester, Pennsylvania 19380

United States