Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer
Start Date
5/28/2025
Completion Date
10/30/2028
Summary
This study is researching an experimental drug called ubamatamab, also referred to as "study drug". The study is focused on patients who have advanced ovarian cancer. The aim of the study is to see how safe, tolerable, and effective the study drug is on its own and in combination with other anti-cancer drugs (bevacizumab, cemiplimab, fianlimab and a standard chemotherapy drug, pegylated liposomal doxorubicin \[PLD\]), referred to as "combination drugs'. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug and its experimental combinations * How much study drug and fianlimab is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) and its combinations
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Ubamatamab
Bevacizumab
Cemiplimab
Fianlimab
PLD
Sarilumab
Conditions
Locations
The University of Alabama at Birmingham
Birmingham, Alabama 35233
United States
UC San Diego Health
La Jolla, California 92037
United States
Cedars Sinai Medical Center
Los Angeles, California 90048
United States
Mayo Clinic Jacksonville
Jacksonville, Florida 32224
United States
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida 33136
United States
Advent Health Cancer Institute
Orlando, Florida 32804
United States
Tampa General Hospital Cancer Institute
Tampa, Florida 33606
United States
University of Chicago
Chicago, Illinois 60637
United States
The University of Kansas Cancer Center
Westwood, Kansas 66205
United States
Norton Cancer Institute, St. Matthews Clinic
Louisville, Kentucky 40207
United States
Massachusetts General Hospital
Boston, Massachusetts 02114
United States
Karmanos Cancer Institute
Detroit, Michigan 48201
United States
The Ohio State University Comprehensive Cancer Center
Hilliard, Ohio 43026
United States
Providence Cancer Institute
Portland, Oregon 97213
United States
University of Pittsburgh Medical Center, Magee-Womens Hospital
Pittsburgh, Pennsylvania 15213
United States
West Penn Hospital of Allegheny Health Network
Pittsburgh, Pennsylvania 15224
United States
Avera Cancer Institute Sioux Falls
Sioux Falls, South Dakota 57105
United States
UT Southwestern Medical Center
Dallas, Texas 75390
United States
Swedish Cancer Institute
Seattle, Washington 98104
United States
University of Wisconsin
Madison, Wisconsin 53792
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
CancerCare Manitoba
Winnipeg, Manitoba R3E 0V9
Canada
Princess Margaret Cancer Centre
Toronto, Ontario M5G 2M9
Canada
Centre de Santé et de Services Sociaux de la Montérégie-Centre
Greenfield Park, Quebec J4V 2H1
Canada
Research Institute - McGill University Health Centre
Montreal, Quebec H4A 3J1
Canada
Centre Hospitalier Universitaire (CHU) de Quebec - Universite Laval
Québec, G1J 0J9
Canada
National Cancer Center
Gyeonggi-do, Gyeonggi-do 10408
South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Gachon University Gil Medical Center
Incheon, Seoul 21565
South Korea
Keimyung University Dongsan Hospital
Daegu, 42601
South Korea
Severance Hospital Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center, Univ. of Ulsan
Seoul, 05505
South Korea
Samsung Medical Center
Seoul, 06351
South Korea
Gangnam Severance Hospital
Seoul, 135-720
South Korea
Seoul National University Hospital
Seoul, 3080
South Korea
Korea University Guro Hospital
Seoul, 8308
South Korea
Changhua Christian Hospital
Changhua, Changhua City 500
Taiwan
Chi Mei Medical Center
Tainan, 71004
Taiwan
Mackay Memorial Hospital
Taipei, 10449
Taiwan
National Taiwan University Hospital
Taipei, 106
Taiwan
Taipei Veterans General Hospital
Taipei, 11211
Taiwan
Tri-Service General Hospital
Taipei, 114202
Taiwan
Taipei Municipal Wan Fang Hospital
Taipei, 116
Taiwan
Medicalpark Seyhan Hospital
Seyhan, Adana 01140
Turkey (Türkiye)
Hacettepe University
Altındağ, Ankara 06240
Turkey (Türkiye)
Medipol University Hospital
Istanbul, Bagcilar 34284
Turkey (Türkiye)
Gaziantep Medicalpoint Hospital
Gaziantep, Sehitkamil 27584
Turkey (Türkiye)
Baskent University
Adana, 01123
Turkey (Türkiye)
Sbu Doctor Abdurrahman Yurtaslan Ankara Onkoloji Suam
Ankara, 06100
Turkey (Türkiye)
Ankara Bilkent City Hospital
Ankara, 06200
Turkey (Türkiye)
Memorial Ankara Hospital
Ankara, 0906520
Turkey (Türkiye)
Cerrahpasa Medical Faculty At Istanbul University Cerrahpasa
Istanbul, 34450
Turkey (Türkiye)
Izmir Ekonomi Universitesi (IEU) Medical Point Izmir Hastanesi (Izmir Economy University Medical Point Izmir Hospital)
Izmir, 35575
Turkey (Türkiye)
Sakarya University - Education and Research Hospital
Sakarya, 54290
Turkey (Türkiye)