NCT06821776NARecruiting

Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

Le Bonheur Children's Hospital

Start Date

2/5/2025

Completion Date

2/1/2030

Summary

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Eligibility Criteria

Age Range: No minimum to 1 years

Inclusion Criteria: * Patients born \<32 weeks' gestation * Currently admitted to the Le Bonheur NICU * Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA) * Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance. Exclusion Criteria: * Known gastrointestinal anomalies * Unable to tolerate ≥100mL/kg/day enteral feeding * Congenital anomalies likely to alter feeding techniques * Surgical feeding tube in place or expected within the next 8 weeks * Expected to remain hospitalized \<8 weeks

Interventions

PROCEDURE

Gastric feeding

PROCEDURE

Transpyloric feeding

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Conditions

Bronchopulmonary DysplasiaFeeding Intolerance

Locations

Le Bonheur Children's Hospital

Memphis, Tennessee 38103

United States