NCT06830980NARecruiting

Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

Gopalkumar Rakesh

Start Date

3/11/2025

Completion Date

12/31/2026

Summary

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.

Detailed Description

The investigators will compare how two theta burst paradigms, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), compare with sham TMS in changing methamphetamine craving and brain activity. iTBS, cTBS, and sham TMS will be delivered in an accelerated fashion (two sessions daily, separated by 50 minutes). iTBS will be delivered to the left dorsolateral prefrontal cortex (left dorsolateral prefrontal cortex), and cTBS will be delivered to the frontal pole. A brain MRI scan will be done before and after the iTBS/cTBS/sham TMS sessions. The study involves four visits. Each visit will last three hours. Hence, participants will spend a total of 12 hours in the study.

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: * Adults in the age group 18-65 years * Able to read and understand English * Able to provide informed consent * Diagnosed with HIV * History of current or previous Methamphetamine Use Disorder * Endorse craving for methamphetamine * Demonstrate an attentional bias for methamphetamine Exclusion Criteria: * Traumatic brain injury * h/o seizure disorder * h/o or current diagnosis of schizophrenia * intracranial metal shrapnel * previous adverse effects with TMS * sub-threshold consistency while performing behavioral tasks * lack of attentional bias to methamphetamine cues * a positive pregnancy test for female participants * abnormal brain MRI

Interventions

DEVICE

intermittent theta burst stimulation (iTBS)

DEVICE

continuous theta burst stimulation (cTBS)

DEVICE

Sham TMS

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Conditions

Methamphetamine Use DisordersHIV

Locations

UK Department of Psychiatry

Lexington, Kentucky 40509

United States