NCT06860711PHASE4Recruiting
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
University of Colorado, Denver
Start Date
7/22/2025
Completion Date
12/1/2028
Summary
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.
Eligibility Criteria
Age Range: No minimum to 25 years
Inclusion Criteria:
* Patients over 18 months of age
* diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
* Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital
Exclusion Criteria:
* Diagnosis of CKD stage 1 or 4-5
* Past medical history of renal transplant
* Past medical history of nasal polyp
* Procedure for oncologic indications or on chemotherapy
* Pregnant patient
* True allergy to NSAIDs
Interventions
DRUG
NSAIDs
DRUG
Placebo
Conditions
Chronic Kidney DiseasePediatric Urology
Locations
Children's Hospital Colorado
Aurora, Colorado 80045
United States