NCT06863233PHASE1Recruiting
A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
Start Date
3/3/2025
Completion Date
3/3/2028
Summary
The purpose of this study to learn whether PET/CT (positron emission tomography/computed tomography) scans using an imaging agent (radiotracer) called zirconium Zr 89 crefmirlimab berdoxam is a safe and effective way to identify CD8+ T cells
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Patient must be 18 years of age or older at the time of signing the informed consent.
* Patient has a histologically confirmed diagnosis of metastatic non-small cell lung cancer
* Patient is enrolled in the engineered TIL cell therapy protocol OBX115-23-01, but has not received the treatment yet.
* Men and women of child-producing potential, use of effective double barrier contraceptive methods during the study, up to 30 days after the last administration of the investigational product.
* Patient or legally authorized representative provided signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
* Patient or legally authorized representative provided written authorization for use and disclosure of protected health information.
Exclusion Criteria:
* Pregnant or breastfeeding women
* Patients with a history of splenectomy or significant splenic dysfunction (e.g., as evidenced by splenomegaly or a history of recurrent infections due to impaired immune function)
Interventions
DRUG
Zirconium Zr 89 crefmirlimab berdoxam
DIAGNOSTIC_TEST
PET/CT Scan
Conditions
Lung CancerNon Small Cell Lung CancerMetastatic Non Small Cell Lung Cancer
Locations
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth (Consent Only)
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey 07645
United States
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only)
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester (Consent only)
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center (All protocol activities)
New York, New York 10065
United States
Memorial Sloan Kettering Cancer Center @ Nassau (Consent only)
Uniondale, New York 11553
United States