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NCT06869512NARecruiting

Cooperative Extension and Cancer Survivorship

University of Oklahoma

Start Date

2/24/2025

Completion Date

12/31/2026

Summary

The goal of this clinical trial is to learn if a cancer survivor program, delivered via Cooperative Extension, is feasible and if it can improve health outcomes in cancer survivors who are post-active treatment. Aim 1: Evaluate the feasibility and acceptability of SUCCESS. Hypothesis 1: SUCCESS will be feasible and acceptable as evidenced by delivery of the intervention among Educators (implementation), including in agreement with the curriculum in Phase 1 (fidelity) with \>85% attendance (demand) among participants with \>80% rating the intervention as acceptable or highly acceptable on 5-point Likert-type scale (acceptability). Aim 2: Determine the preliminary efficacy of SUCCESS for improving HRQOL (primary outcome) and other psychosocial and health-related endpoints (e.g., financial toxicity) (secondary outcomes). Hypothesis 2: Compared to matched controls, adults LWBC who complete SUCCESS will have significant improvements in HRQOL per the PROMIS Global Health v1.2 at follow-up (i.e., after 6 weeks). Aim 3: Examine changes in conserved transcriptional response to adversity (CTRA) gene expression in a subset of interventions participants at follow-up. Hypothesis 3: Adults LWBC who complete SUCCESS will experience significant CTRA down-regulation. This is a single arm trial and there is no comparison group. Participants will be asked to do survey- and Zoom-based data collection before and after completing the 6-week program.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Previous adult-diagnosed cancer * Post active cancer treatment * No current active treatment, hormonal therapy permitted * Ability to get to group sessions * In Oklahoma Exclusion Criteria: * Current palliative or hospice care * Surgical or medical history that precludes participation * Positive screen on the Physical Activity Readiness Questionnaire+ (PAR-Q+) without a doctor's note approving study participation

Interventions

BEHAVIORAL

SUCCESS

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Conditions

Cancer Survivorship

Locations

University of Oklahoma

Tulsa, Oklahoma 74135

United States