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NCT06888024NARecruitingAccepts Healthy Volunteers

Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

Ningcheng Peter Li

Start Date

4/1/2025

Completion Date

1/1/2027

Summary

The purpose of the study is to quantitatively characterize the flow in the pelvic venous structures using 2D and 4D flow MRI with the objective of establishing physiologic and pathologic parameters for downstream computational fluid dynamics analysis. Arm 1: To establish the baseline flow characteristics of the iliac veins in patients with no imaging evidence of iliac venous disease. Arm 2: To assess the flow characteristics of the iliac veins in patients with left iliac vein compression syndrome (a.k.a. May-Thurner syndrome). Arm 3: To assess the flow characteristics of the iliac veins in patients status post iliac stent placement.

Eligibility Criteria

Age Range: 18 years to 89 years

Arm 1: Inclusion Criteria: • No self-reported history of pelvic or iliac venous disease or associated symptoms Exclusion Criteria: * History of pelvic or iliac venous disease or intervention * Contraindication to MRI examination * Prisoners * Subjects ≤ 18 years of age * Pregnant women * Adults unable to provide informed consent Arm 2: Inclusion Criteria: • Clinical symptoms or imaging findings compatible with left iliac vein compression syndrome Exclusion Criteria: * History of pelvic or iliac venous intervention * Contraindication to MRI examination * Prisoners * Subjects ≤ 18 years of age * Pregnant women * Adults unable to provide informed consent Arm 3: Inclusion Criteria: • History of left iliac vein stent placement Exclusion Criteria: * Contraindication to MRI examination * Prisoners * Subjects ≤ 18 years of age * Pregnant women * Adults unable to provide informed consent

Interventions

PROCEDURE

non-contrast enhanced abdomen and pelvis MRI

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Conditions

May-Thurner SyndromeIliac Venous Compression

Locations

University of Massachusetts

Worcester, Massachusetts 01655

United States