NCT06904287PHASE3Recruiting
Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
Wake Forest University Health Sciences
Start Date
12/16/2025
Completion Date
6/1/2027
Summary
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
Detailed Description
The purpose of this prospective, randomized, double-blinded study is to compare the relative efficacy and safety of intravenous magnesium in conjunction with intravenous prochlorperazine in the treatment of migraines. Participants will be patients presenting to the Emergency Department with primary diagnosis of migraine.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Age ≥ 18 years or older
* Able to provide informed consent
* English speaking
* Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics
Exclusion Criteria:
* Pregnancy defined as a positive urine HCG
* Allergy or sensitivity to study drug
* Stated history of renal insufficiency
* Documented history of myasthenia gravis
* Consumption of study drug within 48 hours prior to enrollment
* Previously enrolled in this trial during a different patient encounter
Interventions
DRUG
Magnesium
DRUG
Placebo
Conditions
Migraine
Locations
Advocate Christ Medical Center Emergency Department
Oak Lawn, Illinois 60453
United States