Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
Start Date
9/3/2025
Completion Date
6/30/2028
Summary
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Lidocaine
Diphenhydramine
Conditions
Locations
Bethesda Hospital East
Boynton Beach, Florida 33435
United States