NCT06911229NARecruiting
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
University of Florida
Start Date
10/1/2025
Completion Date
7/31/2027
Summary
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Detailed Description
We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.
Eligibility Criteria
Age Range: 18 years to 80 years
Inclusion Criteria:
* consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
* chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
* Age between 18 - 80 years old per the FDA data sheet for PD DBS;
* no dementia according to the clinical diagnostic criteria for PD dementia;
* ambulatory without the use of walking aids, or another person's assistance.
Exclusion Criteria:
* other previous neurological surgery;
* suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.
Interventions
DEVICE
Deep Brain Stimulation (DBS)
Conditions
Parkinson Disease
Locations
University of Florida
Gainesville, Florida 32611
United States