Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
Start Date
8/7/2025
Completion Date
7/1/2030
Summary
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
Detailed Description
The study's goals involve understanding how transcutaneous stimulation affects motor deficits across three dimensions; weakness, coordination, and spasticity. This will be investigated by an electrophysiological characterization lower-extremity deficits, using TS to interrogate neuromotor topography and connectivity of the spinal cord to specific muscles. These evaluations will enable a unique patient-specific understanding of the electrophysiological mechanisms underlying motor deficits. Furthermore, these evaluations will assess the therapeutic potential of a novel closed-loop TS plasticity induction protocol to strengthen weakened muscles in a pediatric SB population.
Eligibility Criteria
Age Range: 5 years to 18 years
Interventions
Transcutaneous stimulation
Conditions
Locations
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States