A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
Start Date
2/10/2025
Completion Date
6/1/2029
Summary
This is a randomized controlled trial testing the efficacy of Resilience Training in college students with elevated transdiagnostic risk for developing a serious mental illness.
Detailed Description
This is a definitive, randomized controlled trial that will measure the efficacy of Resilience Training, a four-session group-based behavioral intervention conducted in transdiagnostically at-risk young adults who have psychotic experiences. The primary goal is to determine whether Resilience Training is superior to a time-matched active control condition, Life Skills Training, in reducing transdiagnostic symptoms of psychopathology, such as psychotic experiences, and improving long-term psychiatric (preventing the onset of psychiatric diagnoses) and functional (improving academic performance and retention in college) outcomes in this at-risk population. In addition, a proposed model of the mechanisms of action of RT, involving reducing emotion reactivity and changes in hippocampal function and connectivity, will be assessed.
Eligibility Criteria
Age Range: 18 years to 30 years
Interventions
Resilience Training (RT)
Life Skills Training (LST)
Conditions
Locations
Massachusetts General Hospital
Charlestown, Massachusetts 02129
United States