NCT06937671NARecruiting

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

The Cleveland Clinic

Start Date

5/1/2025

Completion Date

12/1/2026

Summary

The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult patient (age 18 years or older) * Polyp size of at least 20 mm * \- Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above) Exclusion Criteria: * Polyps with previous failed resection attempts or polyp recurrence * Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma) * Polyps with nodules too large (\>1-1.5cm) for the use of a cold snare * Inflammatory bowel disease

Interventions

PROCEDURE

Cold EMR

PROCEDURE

Hybrid EMR

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Polyp of ColonEndoscopic Mucosal Resection

Locations

Cleveland Clinic Weston

Weston, Florida 33331

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States