NCT06948136PHASE1RecruitingAccepts Healthy Volunteers

Acute Effects of THC in Older Adult

Yale University

Start Date

6/6/2025

Completion Date

11/1/2027

Summary

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

Eligibility Criteria

Age Range: 21 years to No maximum

* Ability to provide informed consent * No history (current or past) of unstable or serious medical, neurological or psychiatric conditions. * High school education or greater * No positive pregnancy test and/or lactation/ planning to nurse while in this study * English speaking

Interventions

DRUG

Delta-9-THC Low Dose

DRUG

Placebo

DRUG

Delta-9-THC Medium Dose

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Age-related Cognitive Decline

Locations

VA Connecticut Healthcare System

West Haven, Connecticut 06516

United States