Characterizing the Genomic Landscape of Cancer in Native American Populations (NAT-Geno)

Summary

The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prespecified cancers of interest. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.

Detailed Description

This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC) and Renal cell carcinoma (RCC) , focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohorts. Oversight will be maintained by the Institutional Review Board and an independent Native American Advisory Board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. The overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.

Eligibility Criteria

Interventions