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NCT06974279NARecruiting

Post-Stroke Aphasia TMS

Medical College of Wisconsin

Start Date

9/1/2025

Completion Date

12/31/2036

Summary

The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

Detailed Description

In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke aphasia.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Diagnosed with left hemisphere stroke * Consent date \>= 1 month after stroke onset * Fluent in English * 18 years of age or older Exclusion Criteria: * Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing * Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease) * A chronic medical condition that is not treated or is unstable * The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips) * Pregnancy * History of skull fractures, or skin diseases * History of ongoing or unmanaged seizures * Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users) * History of dyslexia or other developmental learning disabilities

Interventions

DEVICE

Precision TMS with SFA

DEVICE

Control TMS with SFA

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Conditions

AphasiaStrokeLanguage

Locations

Medical College of Wisconsin

Milwaukee, Wisconsin 53226

United States