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NCT06978725PHASE2Recruiting

A Phase 2 Study of the Safety and Efficacy of Brepocitinib in Adults With Cutaneous Sarcoidosis (BEACON)

Priovant Therapeutics, Inc.

Start Date

4/9/2025

Completion Date

12/1/2026

Summary

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with cutaneous sarcoidosis.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: 1. Adults subjects (18-74) 2. Cutaneous sarcoidosis with characteristic skin biopsy histology 3. A CSAMI activity score ≥ 10 4. Weight \> 40 kg to \< 130 kg with BMI \< 40 kg/m2 . Exclusion Criteria 1. History of * Lymphoproliferative disorder * Active malignancy; * History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, or carcinoma in situ of the uterine cervix). 2. High risk of thrombosis or cardiovascular disease 3. High risk of herpes zoster 4. Active or recent infection

Interventions

DRUG

Oral Brepocitinib

DRUG

Oral Placebo

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Conditions

Cutaneous Sarcoidosis

Locations

Clinical Trial Site

San Francisco, California 94115

United States

Clinical Trial Site

Durham, North Carolina 27703

United States

Clinical Trial Site

Philadelphia, Pennsylvania 19104

United States

Clinical Trial Site

Madison, Wisconsin 53715

United States