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NCT06982508PHASE2RecruitingAccepts Healthy Volunteers

Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers

NewAmsterdam Pharma

Start Date

9/9/2025

Completion Date

12/1/2026

Summary

The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue. The main questions it aims to answer are: Do Obicetrapib effect absorption of antioxidants in a person's blood or their eye tissue? Researchers will compare Obicetrapib to a placebo (a look-alike substance that contains no drug) to see if Obicetrapib helps improve a person's ability to absorb antioxidants. Participants will: Take Obicetrapib or a placebo every day for 4 months Visit the clinic once every 8 weeks for checkups and tests Have their blood taken and their eyes checked to measure antioxidant levels

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: * Visual acuity \> 20/60 in both eyes with or without corrective lenses Exclusion Criteria: * Type 2 diabetes * Active liver disease * Any clinically significant macular pathology

Interventions

DRUG

Obicetrapib 10mg

DRUG

Placebo

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Conditions

Antioxidant Absorption

Locations

Excellence Medical Research

Miami Gardens, Florida 33169

United States