A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Start Date
6/19/2025
Completion Date
12/14/2027
Summary
The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
Detailed Description
All participants in this study will take either the study medicine (PF-07328948) tablets, or placebo tablets, once daily, by mouth, every day for 36 weeks. The study determines if the study medicine (PF-07328948) is safe and effective compared to placebo in people with heart failure who are already taking standard-of-care medications for heart failure that include sodium-glucose cotransporter 2 (SGLT2) inhibitors. Participants will be involved in this study for about 48 weeks. During this time, participants will visit the study clinic 15 times. In general, 5 of these visits may be performed at home by phone and the other 10 visits will take place at the study site.
Eligibility Criteria
Age Range: 18 years to 79 years
Interventions
Placebo
Low Dose PF-07328948
Medium Dose PF-07328948
High Dose PF-07328948
Conditions
Locations
National Heart Institute
Beverly Hills, California 90211
United States
Orange County Research Center
Lake Forest, California 92630
United States
Comprehensive Cardiovascular Care
Santa Maria, California 93454
United States
FOMAT Medical Research
Santa Maria, California 93454
United States
FWD Clinical Research
Boca Raton, Florida 33486
United States
Jacksonville Center for Clinical Research
Jacksonville, Florida 32216
United States
Infinite Clinical Research
Miami, Florida 33133
United States
Flourish Research Acquisition, LLC dba Flourish Research - North Miami
Miami, Florida 33138
United States
Amavita Research Services
North Miami Beach, Florida 33169
United States
Clinical Site Partners, LLC dba Flourish Research
Winter Park, Florida 32789
United States
NMH Clinical Research Unit
Chicago, Illinois 60611
United States
Northwestern Memorial HealthCare - Arkes Pavilion
Chicago, Illinois 60611
United States
Northwestern Memorial HealthCare - Feinberg Pavilion
Chicago, Illinois 60611
United States
Northwestern Memorial HealthCare - Galter Pavilion
Chicago, Illinois 60611
United States
Northwestern Memorial Hospital Investigational Drug Service (IDS)
Chicago, Illinois 60611
United States
Northwestern University
Evanston, Illinois 60208
United States
Chicago Medical Research
Hazel Crest, Illinois 60429
United States
NexGen Research
Fort Wayne, Indiana 46804
United States
Reid Physician Associates
Richmond, Indiana 47374
United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland 21229
United States
Chesapeake Cardiac Care
Bowie, Maryland 20715
United States
Flourish Research - Bowie
Bowie, Maryland 20715
United States
Velocity Clinical Research, Lincoln, Pioneer Heart Institute
Lincoln, Nebraska 68510
United States
NexGen Research
Lima, Ohio 45801
United States
Headlands Horizons, LLC dba Headlands Research-Brownsville
Brownsville, Texas 78526
United States
Valley Regional Medical Center
Brownsville, Texas 78526
United States
North Dallas Research Associates
McKinney, Texas 75069
United States
Northwest Houston Heart Center
Tomball, Texas 77375
United States
L2IP - Instituto de Pesquisas Clínicas
Brasília, Federal District 70.200-730
Brazil
L2IP - Instituto de Pesquisas Clínicas
Brasília, Federal District 70200730
Brazil
Cardresearch - Cardiologia Assistencial e Pesquisa
Belo Horizonte, Minas Gerais 30150-274
Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul 90430-001
Brazil
CoraCentro Pesquisa Clinica
Porto Alegre, Rio Grande do Sul 90840-440
Brazil
Instituto de Pesquisa clinica de Campinas
Campinas, São Paulo 13060-080
Brazil
Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping
Ribeirão Preto, São Paulo 14026-900
Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo 15090000
Brazil
UNESP - Faculdade de Medicina da Universidade Estadual Paulista
Botucatu, SÃO PAUL 18618-970
Brazil
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, 04266-010
Brazil
Incor - Instituto do Coracao
São Paulo, 05403-000
Brazil
Diagnostic Consultative Center - 1 Lom EOOD
Lom, Montana 3600
Bulgaria
Diagnostic Consultative Center "Ascendent"
Sofia, Sofia (stolitsa) 1202
Bulgaria
Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD
Sofia, Sofia (stolitsa) 1233
Bulgaria
Diagnostic Consultative Center Aleksandrovska
Sofia, Sofia (stolitsa) 1431
Bulgaria
University Multiprofile Hospital for Active Treatment Sveta Ekaterina EAD
Sofia, Sofia (stolitsa) 1431
Bulgaria
"Multiprofile Hospital for Active Treatment Puls" AD
Blagoevgrad, 2700
Bulgaria
Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD
Gabrovo, 5300
Bulgaria
Medical Center Hera - Kyustendil EOOD
Kyustendil, 2500
Bulgaria
MHAT - Heart and Brain
Pleven, 5804
Bulgaria
University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
Plovdiv, 4002
Bulgaria
MHAT Hadzhi Dimitar
Sliven, 8800
Bulgaria
Аcibadem City Clinic University MHAT EOOD - Third Clinical Base
Sofia, 1415
Bulgaria
Medical Center Hera EOOD
Sofia, 1510
Bulgaria
Richmond Clinical Trials
Richmond, British Columbia V6V 2L1
Canada
QEII Health Sciences Centre - Victoria General Site
Halifax, Nova Scotia B3H 3A7
Canada
Health Sciences North Research Institute
Greater Sudbury, Ontario P3E 5J1
Canada
ACV Clinic
Greater Sudbury, Ontario P3E 5M4
Canada
CardioQuest Research Centre
Sarnia, Ontario N7T 4P5
Canada
Corcare
Toronto, Ontario M1B 5N1
Canada
Community Care Building
Winchester, Ontario K0C 2K0
Canada
Winchester District Memorial Hospital
Winchester, Ontario K0C 2K0
Canada
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec G7H 5H6
Canada
CHU de Quebec - Université Laval - Hotel Dieu de Quebec
Québec, Quebec G1R 2J6
Canada
Clinique de Médecins Spécialistes
Shebrooke, Quebec J1E 0N8
Canada
Diex Recherche Sherbrooke Est
Sherbrooke, Quebec J1E 0N8
Canada
Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur.
Terrebonne, Quebec J6V 2H2
Canada
Diex Recherche Trois-Rivieres
Trois-Rivières, Quebec G9A 4P3
Canada
Peking University First Hospital
Beijing, Beijing Municipality 100034
China
Lanzhou university second hospital
Lanzhou, Gansu 730030
China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong 510080
China
Hainan General Hospital
Haikou, Hainan 570311
China
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei 050031
China
The Second Xiangya Hospital of Central South University
Changsha, Hunan 410011
China
China-Japan Union Hospital
Changchun, Jilin 130033
China
Shaanxi provincial people's hospital
Xi'an, Shaanxi 710068
China
Jinan Central Hospital
Jinan, Shandong 250013
China
Zhongshan Hospital,Fudan University
Shanghai, Shanghai Municipality 200032
China
Shanghai Tongji Hospital
Shanghai, Shanghai Municipality 200065
China
Tianjin People' s Hospital
Tianjin, Tianjin Municipality 300000
China
The First Affiliated Hospital of University of South China
Hengyang,
China
Sdružené Zdravotnické Zařízení Krnov
Krnov, Moravian-Silesian Region 794 01
Czechia
Kardiologicka ambulance Brno s.r.o.
Brno-Královo Pole, 612 00
Czechia
EFERTUS healthcare s.r.o.
Brno-Židenice, 615 00
Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Czechia
EDUMED s.r.o.
Jaroměř, 551 01
Czechia
VASOMED Clinic s.r.o.
Ostrava, 710 00
Czechia
AGEL Stredomoravska nemocnicni, a.s., Nemocnice AGEL Prerov
Přerov, 751 52
Czechia
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, Hérault 34090
France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Saint-Herblain, Loire-atlantique 44800
France
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
Toulon, Provence-Alpes-Côte d'Azur Region 83100
France
Chu Grenoble Alpes
Grenoble, 38700
France
Da Vinci Magánklinika
Pécs, Baranya 7635
Hungary
CMed Rehabilitacios es Diagnosztikai Kozpont
Székesfehérvár, Fejér 8000
Hungary
BKS Research Kft
Hatvan, Heves County 3000
Hungary
Ezüstfény Klinika Kft
Budapest, 1106
Hungary
Semmelweis Egyetem
Budapest, 1122
Hungary
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1134
Hungary
Jahn Ferenc Dél-pesti Hospital
Budapest, 1204
Hungary
New Medical Center Kft.
Sopron, H-9400
Hungary
Kasugai Municipal Hospital
Kasugai, Aichi-ken 486-8510
Japan
Nagoya Tokushukai General Hospital
Kasugai, Aichi-ken 487-0016
Japan
Seikeikai New Tokyo Heart Clinic
Matsudo, Chiba 271-0077
Japan
Toho University Sakura Medical Center
Sakura, Chiba 285-8741
Japan
Teine Keijinkai Hospital
Sapporo, Hokkaido 006-8555
Japan
Koga General Hospital
Koga, Ibaraki 306-0041
Japan
Sagamihara Kyodo Hospital
Sagamihara, Kanagawa 252-5188
Japan
Yokohama Municipal Citizen's Hospital
Yokohama, Kanagawa 221-0855
Japan
National Hospital Organization Yokohama Medical Center
Yokohama, Kanagawa 245-8575
Japan
National Hospital Organization Mie Chuo Medical Center
Tsu, Mie-ken 514-1101
Japan
National Hospital Organization Sendai Medical Center
Sendai, Miyagi 983-8520
Japan
Kishiwada Tokushukai Hospital
Kishiwada, Osaka 596-0042
Japan
National Hospital Organization Saitama Hospital
Wako, Saitama 351-0102
Japan
Tokyo Metropolitan Toshima Hospital
Itabashi-ku, Tokyo 173-0015
Japan
Showa General Hospital
Kodaira-shi, Tokyo 187-8510
Japan
National Hospital Organization Tokyo Medical Center
Meguro-Ku, Tokyo 152-8902
Japan
NewHeart Watanabe Institute
Suginami, Tokyo 168-0065
Japan
Sekino Hospital
Toshimaku, Tokyo 171-0014
Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni, Yamaguchi 740-8510
Japan
Nagasaki Harbor Medical Center
Nagasaki, 850-8555
Japan
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, Greater Poland Voivodeship 61-848
Poland
NZOZ Centrum Medyczne KERmed
Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-231
Poland
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu
Torun, Kuyavian-Pomeranian Voivodeship 87-100
Poland
SP ZOZ w Puławach
Puławy, Lublin Voivodeship 24-100
Poland
NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus
Sopot, Pomeranian Voivodeship 81-717
Poland
Kardio Brynow
Katowice, Silesian Voivodeship 40-555
Poland
Research and Cardiovascular Corp.
Ponce, 00717
Puerto Rico
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [LA Coruña] 15706
Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, Barcelona [barcelona] 08003
Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona] 08035
Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [cataluña] 08041
Spain
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Catalunya [cataluña] 08907
Spain
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid 28220
Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de 28034
Spain
Hospital Universitario La Paz
Madrid, Madrid, Comunidad de 28046
Spain
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat 46010
Spain
Hospital General Universitario de Valencia
Valencia, 46014
Spain
Hospital Universitari i Politecnic La Fe
Valencia, 46026
Spain
Ninewells Hospital and Medical School
Dundee, Dundee CITY DD1 9SY
United Kingdom
St. George's Hospital
London, England SW17 0QT
United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, Norfolk NR4 7UY
United Kingdom
St Richard's Hospital
Chichester, WEST Sussex PO19 6SE
United Kingdom
South Eastern Health and Social Care Trust
Belfast, BT16 1RH
United Kingdom
Wycombe General Hospital
High Wycombe, HP11 2TT
United Kingdom