Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery
Start Date
11/1/2024
Completion Date
6/1/2026
Summary
This is a randomized trial for patients that are diagnosed with Twin-Twin Transfusion Syndrome (TTTS) who are receiving a fetoscopic laser surgery to evaluate the effectiveness and safety of a laparotomy closure.
Detailed Description
The rationale behind suturing the hole is that the amniotic membrane does not close itself, rather you are relying that the uterus closes over the hole in the amniotic membrane, which may or may not happen, as well as in fetoscopic surgery for another condition, myelomeningocele. Published data has shown that maternal laparotomy to suture closure of the port site at the time of fetoscopic surgery leads to improved pregnancy outcomes, later gestational age at delivery, and lower rates of preterm pre-labor rupture of membranes (PPROM) \[PMID: 28910784\].
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Trans-Amniotic Suture Placement
Conditions
Locations
Cincinnati Childrens Hospital Medical Center
Cincinnati, Ohio 45229
United States