NCT07029243NARecruiting
Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis
University of California, San Francisco
Start Date
4/15/2026
Completion Date
12/1/2026
Summary
Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition/exercise prehabilitation app will maintain muscle health in patients with liver disease.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography
* Access to digital device and internet at home
* Ability to provide written informed consent before any study-related activities
* Ability to remain in study for at least 3 months
Exclusion Criteria:
* Allergy to milk protein
* On hemodialysis
* No English language proficiency
* Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data
* Concomitant severe underlying systemic illness that in the opinion of the Investigator would interfere with completion of study
* Pregnant, breastfeeding, or intention of becoming pregnant during study time frame
Interventions
BEHAVIORAL
HEAL-ME digital app
DIETARY_SUPPLEMENT
Creatine supplementation
DIETARY_SUPPLEMENT
Whey protein supplementation
DIETARY_SUPPLEMENT
Placebo
Conditions
CirrhosisFrailtySarcopenia
Locations
University of California San Francisco
San Francisco, California 94143
United States