NCT07031297NARecruitingAccepts Healthy Volunteers

Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Mayo Clinic

Start Date

5/5/2026

Completion Date

5/1/2028

Summary

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Eligibility Criteria

Age Range: 18 years to 55 years

Inclusion Criteria: • All women must be premenopausal Exclusion Criteria: * Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements) * Diabetes, history of cardiovascular disease * Allergy to lidocaine * Post-menopausal women * Pregnant

Interventions

DIAGNOSTIC_TEST

Meal Study

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Conditions

Obesity

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States

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