NCT07033026PHASE2Recruiting

An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

NGM Biopharmaceuticals, Inc

Start Date

6/25/2025

Completion Date

12/1/2027

Summary

A multi-center evaluation of NGM120 in a randomized, double-blind, placebo-controlled study in participants with colorectal cancer who have cancer cachexia.

Detailed Description

Evaluation of Efficacy, Safety and Tolerability of NGM120 in a Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Participants with Colorectal Cancer who have Cancer Cachexia

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Documented active diagnosis of colorectal cancer. 2. Cachexia defined by Fearon criteria of weight loss. 3. Signed informed consent. Exclusion Criteria: 1. Current active reversible causes of decreased food intake. 2. Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization. 3. Have cachexia caused by other reasons.

Interventions

DRUG

NGM120 Q4W

DRUG

NGM120 Q8W

DRUG

Placebo given

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Conditions

Colorectal CancerCRC (Colorectal Cancer)Cancer Cachexia

Locations

NGM Clinical Study Site

Los Angeles, California 90033

United States

NGM Clinical Study Site

Los Angeles, California 90095

United States

NGM Clinical Study Site

Santa Rosa, California 95403

United States

NGM Clinical Study Site

Margate, Florida 33063

United States

NGM Clinical Study Site

Baltimore, Maryland 21201

United States

NGM Clinical Study Site

New York, New York 10065

United States

NGM Clinical Study Site

Toledo, Ohio 43608

United States

NGM Clinical Study Site

Youngstown, Ohio 44504

United States

NGM Clinical Study Site

Dallas, Texas 75390

United States

NGM Clinical Study Site

Kingwood, Texas 77339

United States

NGM Clinical Study Site

Laredo, Texas 78041

United States

NGM Clinical Study Site

Richmond, Virginia 23114

United States

NGM Clinical Study Site

Appleton, Wisconsin 54915

United States

NGM Clinical Study Site

Tbilisi, 159

Georgia

NGM Clinical Study Site

Tbilisi, 159

Georgia

NGM Clinical Study Site

Tbilisi, 159

Georgia

NGM Clinical Study Site

Tbilisi, 159

Georgia

NGM Clinical Study Site

Tbilisi, 186

Georgia

NGM Clinical Study Site

Goyang, 10326

South Korea

NGM Clinical Study Site

Goyang, 1048

South Korea

NGM Clinical Study Site

Incheon, 21565

South Korea

NGM Clinical Study Site

Seoul, 2841

South Korea

NGM Clinical Study Site

Seoul, 3080

South Korea

NGM Clinical Study Site

Seoul, 6351

South Korea

NGM Clinical Study Site

Suwon, 16247

South Korea

NGM Clinical Study Site

Taichung, 407216

Taiwan

NGM Clinical Study Site

Taipei, 100225

Taiwan

NGM Clinical Study Site

Taoyuan, 333423

Taiwan