A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Start Date
7/16/2025
Completion Date
4/30/2029
Summary
Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it
Eligibility Criteria
Age Range: 50 years to 85 years
Interventions
MK-2214
Placebo
Conditions
Locations
Irvine Clinical Research ( Site 1041)
Irvine, California 92614
United States
Healthy Brain Clinic ( Site 1005)
Long Beach, California 90804
United States
Inglewood Clinical ( Site 1062)
Los Angeles, California 90056
United States
Anderson Clinical Research ( Site 1024)
Redlands, California 92374
United States
UCSF Memory and Aging Center ( Site 1031)
San Francisco, California 94158
United States
Syrentis Clinical Research ( Site 1001)
Santa Ana, California 92705
United States
Yale University, Alzheimer's Disease Research Unit ( Site 1059)
New Haven, Connecticut 06510
United States
JEM Research Institute ( Site 1046)
Atlantis, Florida 33462
United States
Neuropsychiatric Research Center of Southwest Florida ( Site 1003)
Fort Myers, Florida 33912
United States
K2 Medical Research ( Site 1047)
Maitland, Florida 32750
United States
ClinCloud LLC ( Site 1039)
Melbourne, Florida 32940
United States
Indago Research and Health Center Inc ( Site 1044)
Miami Lakes, Florida 33016
United States
Aqualane Clinical Research ( Site 1035)
Naples, Florida 34105
United States
Suncoast Clinical Research ( Site 1007)
New Port Richey, Florida 34652
United States
Renstar Medical Research ( Site 1012)
Ocala, Florida 34471
United States
Charter Research - Orlando ( Site 1051)
Orlando, Florida 32803
United States
Axiom Brain Health ( Site 1029)
Tampa, Florida 33609
United States
K2 Medical Research ( Site 1020)
Tampa, Florida 33634
United States
Charter Research - Lady Lake ( Site 1019)
The Villages, Florida 32162
United States
Conquest Research LLC ( Site 1053)
Winter Park, Florida 32789
United States
CenExel iResearch, LLC ( Site 1015)
Decatur, Georgia 30030
United States
Alexian Brothers Medical Center-Neurosciences ( Site 1017)
Elk Grove Village, Illinois 60007
United States
Boston Center for Memory ( Site 1008)
Newton, Massachusetts 02459
United States
Clinical Research Professionals ( Site 1004)
Chesterfield, Missouri 63005
United States
The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)
Ridgewood, New Jersey 07450
United States
The Cognitive and Research Center of NJ ( Site 1057)
Springfield, New Jersey 07081
United States
CenExel- AMRI ( Site 1018)
Toms River, New Jersey 08755
United States
Alzheimer Disease Research Center (ADRC) ( Site 1000)
Albany, New York 12208
United States
Mid Hudson Medical Research ( Site 1050)
New Windsor, New York 12553
United States
Basil Clinical ( Site 1065)
Queens, New York 11413
United States
AMC Research, LLC ( Site 1006)
Matthews, North Carolina 28105
United States
Insight Clinical Trials ( Site 1011)
Independence, Ohio 44131
United States
Neuro-Behavioral Clinical Research ( Site 1028)
North Canton, Ohio 44720
United States
Flourish Research ( Site 1048)
Plymouth Meeting, Pennsylvania 19462
United States
Gadolin Research ( Site 1032)
Beaumont, Texas 77702
United States
Horizon Clinical Research Center - Houston ( Site 1026)
Cypress, Texas 77429
United States
Organizacion Medica de Investigacion ( Site 0401)
Ciudad de Buenos Aires, Buenos Aires F.D. C1015ABO
Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0404)
Ciudad de Buenos Aires, Buenos Aires F.D. C1431FWO
Argentina
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) ( Site 0400)
Caba, C1428AQK
Argentina
Southern Neurology ( Site 0306)
Kogarah, New South Wales 2217
Australia
KARA Institute for Neurological Diseases ( Site 0302)
Macquarie Park, New South Wales 2113
Australia
Austin Health ( Site 0300)
Ivanhoe, Victoria 3079
Australia
HammondCare ( Site 0301)
Malvern, Victoria 3144
Australia
Cliniques universitaires Saint-Luc ( Site 3001)
Brussels, Bruxelles-Capitale, Region de 1200
Belgium
UZ Leuven ( Site 3000)
Leuven, Vlaams-Brabant 3000
Belgium
AZ Groeninge Campus Kennedylaan ( Site 3002)
Kortrijk, West-Vlaanderen 8500
Belgium
Ottawa Memory Clinic ( Site 2001)
Ottawa, Ontario K1Z 1G3
Canada
Sunnybrook Research Institute ( Site 2003)
Toronto, Ontario M4N 3M5
Canada
Toronto Western Hospital ( Site 2004)
Toronto, Ontario M5T 2S8
Canada
Clinique Mémoire de Montreal ( Site 2000)
Montreal, Quebec H3G 1H9
Canada
National Center for Geriatrics and Gerontology ( Site 9002)
Ōbu, Aichi-ken 474-8511
Japan
Chibaken Saiseikai Narashino Hospital ( Site 9000)
Narashino, Chiba 275-8580
Japan
Association of Healthcare Corporation Koukankai Koukan Clinic ( Site 9016)
Kawasaki, Kanagawa 210-0852
Japan
Mie University Hospital ( Site 9011)
Tsu, Mie-ken 514-8507
Japan
Katayama Medical Clinic ( Site 9005)
Kurashiki, Okayama-ken 710-0813
Japan
National Hospital Organization Hizen Psychiatric Medical Center ( Site 9004)
Kanzaki-gun, Saga-ken 8420192
Japan
Tokyo Medical University Hospital ( Site 9003)
Shinjuku, Tokyo 160-0023
Japan
Inage Neurology and Memory Clinic ( Site 9001)
Chiba, 263-0043
Japan
Kyushu University Hospital ( Site 9010)
Fukuoka, 812-8582
Japan
Okayama City General Medical Center Okayama City Hospital ( Site 9008)
Okayama, 700-8557
Japan
Brain Research Center Den Bosch B.V. ( Site 5001)
's-Hertogenbosch, North Brabant 5223 LA
Netherlands
Brain Research Center. ( Site 5000)
Amsterdam, North Holland 1081 GN
Netherlands
Brain Research Center Zwolle ( Site 5002)
Zwolle, Overijssel 8025 AZ
Netherlands
National Neuroscience Institute ( Site 0101)
Singapore, Central Singapore 308433
Singapore
Tan Tock Seng Hospital ( Site 0102)
Singapore, Central Singapore 308433
Singapore
Hanyang University Hospital ( Site 0200)
Seoul, 04763
South Korea
Samsung Medical Center ( Site 0202)
Seoul, 06351
South Korea
Ewha Womans University Seoul Hospital ( Site 0201)
Seoul, 07804
South Korea
Hospital Universitari Mutua Terrassa ( Site 6004)
Terrassa, Barcelona 08222
Spain
Fundació ACE ( Site 6003)
Barcelona, Catalonia 08028
Spain
Hospital del Mar ( Site 6001)
Barcelona, 08003
Spain
Hospital Clinic i Provincial ( Site 6002)
Barcelona, 08036
Spain
Scottish Brain Sciences Aberdeen ( Site 8001)
Aberdeen, Aberdeen City AB25 2XE
United Kingdom
Scottish Brain Sciences ( Site 8000)
Edinburgh, Edinburgh, City of EH12 5PJ
United Kingdom
Moorgreen Hospital ( Site 8004)
Southampton, Hampshire SO30 3JB
United Kingdom
Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
London, London, City of NW1 2PG
United Kingdom
Warneford Hospital ( Site 8007)
Oxford, Oxfordshire OX3 7JX
United Kingdom
Remind UK ( Site 8003)
Bath, Somerset BA1 3NG
United Kingdom
Re:Cognition Health - Birmingham ( Site 8002)
Birmingham, B16 8LT
United Kingdom