NCT07063732NARecruitingAccepts Healthy Volunteers

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

McMaster University

Start Date

5/28/2025

Completion Date

8/31/2025

Summary

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Eligibility Criteria

Age Range: 18 years to 35 years

Inclusion Criteria: \- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California Exclusion Criteria: * BMI \> 30 * No prescribed medications (oral contraceptives excluded) * History of smoking * Currently following a ketogenic diet or consuming exogenous ketogenic supplements * History of heart, lung, blood vessel, or kidney disease * Currently pregnant

Interventions

DIETARY_SUPPLEMENT

Ketone Monoester (KME)

DIETARY_SUPPLEMENT

Placebo

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Conditions

High Altitude HypoxiaExercise

Locations

Barcroft Research Station

Bishop, California 93514

United States

University of Guelph

Guelph, Ontario N1G 2W1

Canada