NCT07065747RecruitingAccepts Healthy Volunteers
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
Oregon Health and Science University
Start Date
9/1/2024
Completion Date
12/1/2026
Summary
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.
Eligibility Criteria
Age Range: 5 years to 85 years
Inclusion Criteria:
1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.
Exclusion Criteria:
1. Inability to give informed consent.
2. Inability to maintain stable fixation for OCT imaging.
3. Inability to commit to required visits to complete the study.
4. Pregnancy and breastfeeding.
Conditions
Anterior Uveitis (AU)Birdshot ChorioretinitisBehcet DiseaseHerpes Simplex VirusJuvenile Idiopathic Arthritis (JIA)Spondyloarthritis (SA)SarcoidosisPosterior Vitreous Detachment
Locations
Casey Eye Institute - Oregon Health & Science University
Portland, Oregon 97239
United States