NCT07069478NARecruitingAccepts Healthy Volunteers
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
University of Minnesota
Start Date
6/16/2025
Completion Date
12/31/2028
Summary
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
Eligibility Criteria
Age Range: 21 years to 70 years
Inclusion Criteria:
* Adults who are relatively healthy and aged 21-70 years.
* Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
* Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
Exclusion Criteria:
* Participated in previous acute stress studies that included a similar stress induction.
* Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
* Self-reported current pregnancy.
* Self-reported current use of illicit substances (other than cannabis).
* Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
* Students of the principal researcher
Interventions
OTHER
Stress Intervention
Conditions
CBDCannabidiolStressAcute Stress Reaction
Locations
University of Minnesota
Minneapolis, Minnesota 55455
United States