NCT07090161PHASE2Recruiting

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Vanda Pharmaceuticals

Start Date

9/15/2025

Completion Date

11/1/2026

Summary

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: * SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies Exclusion Criteria: * Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency

Interventions

DRUG

iloperidone

DRUG

Placebo

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Conditions

HypertensionUncontrolled Hypertension

Locations

Vanda Investigative Site

Phoenix, Arizona 85053

United States

Vanda Investigative Site

Tempe, Arizona 85281

United States

Vanda Investigative Site

Tucson, Arizona 85715

United States

Vanda Investigative Site

Chula Vista, California 91910

United States

Vanda Investigative Site

Dublin, California 94568

United States

Vanda Investigative Site

Valencia, California 91355

United States

Vanda Investigative Site

Walnut Creek, California 94596

United States

Vanda Investigative Site

Doral, Florida 33172

United States

Vanda Investigative Site

Fort Myers, Florida 33912

United States

Vanda Investigative Site

Columbus, Georgia 31904

United States

Vanda Investigative Site

Oak Brook, Illinois 60523

United States

Vanda Investigative Site

Tinley Park, Illinois 60477

United States

Vanda Investigative Site

El Dorado, Kansas 67042

United States

Vanda Investigative Site

Wichita, Kansas 67226

United States

Vanda Investigative Site

Lexington, Kentucky 40509

United States

Vanda Investigative Site

Hazelwood, Missouri 63042

United States

Vanda Investigative Site

Las Vegas, Nevada 89119

United States

Vanda Investigative Site

Mount Kisco, New York 10549

United States

Vanda Investigative Site

Rochester, New York 14609

United States

Vanda Investigative Site

Kinston, North Carolina 28501

United States

Vanda Investigative Site

Cincinnati, Ohio 45212

United States

Vanda Investigative Site

Norman, Oklahoma 73069

United States

Vanda Investigative Site

Oklahoma City, Oklahoma 73112

United States

Vanda Investigative Site

Charleston, South Carolina 29414

United States

Vanda Investigative Site

Carrollton, Texas 75006

United States

Vanda Investigative Site

Salt Lake City, Utah 84124

United States

Vanda Investigative Site

Burke, Virginia 22015

United States

Vanda Investigative Site

Norfolk, Virginia 23502

United States