NCT07094061NARecruitingAccepts Healthy Volunteers
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
University of Michigan
Start Date
10/3/2025
Completion Date
8/1/2028
Summary
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
Eligibility Criteria
Age Range: 18 years to 22 years
Inclusion Criteria:
* 18-22 years old at baseline
* Right-handed
* Medically/physically able to give informed consent
* English-speaking
* Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
Exclusion Criteria:
* Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
* History of psychosis in self or first-degree relative
* Current treatment for substance use disorder
* Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
* Intelligence quotient (IQ) \< 70
* Lifetime history of head trauma with loss of consciousness \> 5 minutes
* Reliance on glasses to be able to read small text at a distance of approximately 30 inches
* Colorblindness
* MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
Interventions
DEVICE
fMRI
BEHAVIORAL
Questionnaires and surveys
BEHAVIORAL
Behavioral tasks and eye tracking
Conditions
Substance UseHealthy
Locations
Rachel Upjohn Building
Ann Arbor, Michigan 48109
United States
University of Michigan
Ann Arbor, Michigan 48109
United States