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NCT07096453PHASE1, PHASE2Recruiting

CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients

University of Minnesota

Start Date

10/2/2025

Completion Date

8/1/2027

Summary

The purpose of this study is to study how CMVIG interacts with the body and to see if it might work to prevent kidney transplant patients from becoming infected with CMV.

Eligibility Criteria

Age Range: 18 years to 70 years

Inclusion Criteria: * Adult (18-70 year old) kidney transplant recipients * Patients transitioning from conventional CNI-based immunosuppression to co-stimulatory blockade (belatacept) immunosuppression OR patients who are stable on belatacept immunosuppression at the time of initial CYTOGAM infusion * CMV Ig Seronegative Recipient who received a CMV Ig seropositive Donor * EBV IgG Positive Exclusion Criteria: * Pregnant people * Subjects unwilling to sign consent and complete follow up visits * Subjects with IgA immunodeficiency * Subjects who are receiving IgG therapy or who have received IgG therapy within two months of study enrollment * Patients who do not speak English and would need a translator and translated consent materials in order to obtain informed consent

Interventions

DRUG

Cytogam

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Conditions

Kidney Transplant; ComplicationsCMV

Locations

University of Minnesota

Minneapolis, Minnesota 55455

United States