NCT07104539NARecruitingAccepts Healthy Volunteers
Strength Training Response of Muscle in GLP-1 Users
Virginia Polytechnic Institute and State University
Start Date
10/8/2025
Completion Date
5/1/2027
Summary
GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.
Eligibility Criteria
Age Range: 50 years to No maximum
Inclusion Criteria:
* Age, 50y+
* Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less
* Weight \<300 lb
* Pass a health and exercise readiness screening
Exclusion Criteria:
* Age \<50
* Weight \>300 lb
* Osteoporosis
* Active metabolic, neoplastic, or cardiovascular disease
* Unable or unwilling to provide consent
Interventions
BEHAVIORAL
Strength Training
OTHER
Wait first, then strength training
Conditions
Muscle Mass
Locations
Virginia Tech
Blacksburg, Virginia 24061
United States