NCT07122986PHASE1RecruitingAccepts Healthy Volunteers
A Study to Learn About a Vaccine Against E Coli in Healthy Adults
Pfizer
Start Date
8/11/2025
Completion Date
5/26/2028
Summary
This study evaluates an investigational vaccine designed to protect against Escherichia coli (E coli). The primary objective is to assess the safety and tolerability of E coli vaccines administered intramuscularly to healthy adults.
Eligibility Criteria
Age Range: 18 years to 64 years
Ages Eligible for Study: 18 to 64 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes
Key Inclusion Criteria
1. Adult Participants \>= 18 through \< 64 years of age at the time of enrollment.
2. Healthy participants as determined by medical history, physical examination, and clinical judgement of the investigator to be eligible for inclusion in the study.
Key Exclusion Criteria
1. Severe adverse reaction history associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s).
2. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination.
3. Women who are pregnant, plan to become pregnant during the study, or are breastfeeding.
Interventions
DRUG
E coli vaccine 1 Dose A
DRUG
E coli vaccine 1 Dose B
DRUG
E coli vaccine 2
DRUG
E coli vaccine 3
DRUG
E coli Vaccine 4 Dose A
DRUG
E coli Vaccine 4 Dose B
DRUG
E coli Vaccine 4 Dose C
DRUG
E coli Vaccine 5 Dose A
DRUG
E coli Vaccine 5 Dose B
DRUG
Placebo
Conditions
Healthy Participants
Locations
Anaheim Clinical Trials, LLC
Anaheim, California 92801
United States
Orange County Research Center
Lake Forest, California 92630
United States
Diablo Clinical Research, Inc.
Walnut Creek, California 94598
United States
Miami Eye Institute
Hollywood, Florida 33024
United States
Research Centers of America
Hollywood, Florida 33024
United States
NYU Langone Health
New York, New York 10016
United States
CTI Clinical Research Center
Cincinnati, Ohio 45212
United States
Senders Pediatrics
South Euclid, Ohio 44121
United States
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee 37909
United States
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee 37920
United States
University Eye Specialists, P.C. (Ophthalmologist)
Maryville, Tennessee 37803
United States