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NCT07122986PHASE1RecruitingAccepts Healthy Volunteers

A Study to Learn About a Vaccine Against E Coli in Healthy Adults

Pfizer

Start Date

8/11/2025

Completion Date

5/26/2028

Summary

This study evaluates an investigational vaccine designed to protect against Escherichia coli (E coli). The primary objective is to assess the safety and tolerability of E coli vaccines administered intramuscularly to healthy adults.

Eligibility Criteria

Age Range: 18 years to 64 years

Ages Eligible for Study: 18 to 64 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Key Inclusion Criteria 1. Adult Participants \>= 18 through \< 64 years of age at the time of enrollment. 2. Healthy participants as determined by medical history, physical examination, and clinical judgement of the investigator to be eligible for inclusion in the study. Key Exclusion Criteria 1. Severe adverse reaction history associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s). 2. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination. 3. Women who are pregnant, plan to become pregnant during the study, or are breastfeeding.

Interventions

DRUG

E coli vaccine 1 Dose A

DRUG

E coli vaccine 1 Dose B

DRUG

E coli vaccine 2

DRUG

E coli vaccine 3

DRUG

E coli Vaccine 4 Dose A

DRUG

E coli Vaccine 4 Dose B

DRUG

E coli Vaccine 4 Dose C

DRUG

E coli Vaccine 5 Dose A

DRUG

E coli Vaccine 5 Dose B

DRUG

Placebo

Interested in This Trial?

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Conditions

Healthy Participants

Locations

Anaheim Clinical Trials, LLC

Anaheim, California 92801

United States

Orange County Research Center

Lake Forest, California 92630

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Miami Eye Institute

Hollywood, Florida 33024

United States

Research Centers of America

Hollywood, Florida 33024

United States

NYU Langone Health

New York, New York 10016

United States

CTI Clinical Research Center

Cincinnati, Ohio 45212

United States

Senders Pediatrics

South Euclid, Ohio 44121

United States

Alliance for Multispecialty Research, LLC

Knoxville, Tennessee 37909

United States

Alliance for Multispecialty Research, LLC

Knoxville, Tennessee 37920

United States

University Eye Specialists, P.C. (Ophthalmologist)

Maryville, Tennessee 37803

United States