NCT07132645EARLY_PHASE1Recruiting
An Investigational Scan ([68Ga] Ga-FAPI-04 PET/CT) for the Imaging of Patients With High-Grade Neuroendocrine Cancer
University of Michigan Rogel Cancer Center
Start Date
9/16/2025
Completion Date
9/1/2027
Summary
This early phase I trial determines where and to what degree the tracer \[68Ga\] Ga-FAPI-04 accumulates in normal and cancer tissues in patients with high grade neuroendocrine cancer. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research \[68Ga\] Ga-FAPI-04. Because some cancers take up \[68Ga\] Ga-FAPI-04, it can be seen with PET. CT utilizes x-rays that traverse body from the outside. CT images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient's body.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Age ≥ 18 years old
* Current neuroendocrine tumor diagnosis AND high-grade neuroendocrine tumor presentation determined using the following criteria(s):
* Previous low uptake of \[68Ga\] Ga-DOTATATE PET/CT scan OR
* Krenning Score ≥ 3 OR
* Ki67 index ≥ 20%
* Able to lie flat for 60 minutes
* Ability to understand and the willingness to sign a written informed consent
Exclusion Criteria:
* Pregnancy or lactation
* Patient recently underwent surgery with wound healing
Interventions
PROCEDURE
Computed Tomography
DRUG
Gallium Ga 68-DOTA-FAPI-04
PROCEDURE
Positron Emission Tomography
Conditions
Neuroendocrine Tumor
Locations
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United States