NCT07137286Recruiting

A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Mayo Clinic

Start Date

9/11/2025

Completion Date

8/1/2027

Summary

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18 years of age or older * LDL-C \>170 mg/dL in response to starting a ketogenic diet Exclusion Criteria: * Patients who do not consent to blood draw for genetic testing * Those with LDL-C \<170 mg/dL on a ketogenic diet

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Conditions

LDL Hyper-responsiveness

Locations

Mayo Clinic

Rochester, Minnesota 55905

United States