NCT07146685PHASE4Recruiting
Effect of Local Anesthetic Concentration on Rebound Pain
University of Virginia
Start Date
5/13/2026
Completion Date
1/28/2029
Summary
Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Total shoulder replacement patients (anatomic and reverse)
* Adult patients (greater than or equal to 18 years)
* Any gender
* Any race
Exclusion Criteria:
* \- Chronic Pain diagnoses including:
* substance/opioid use disorder
* complex regional pain syndromes
* fibromyalgia
* Daily persistent opioid use spanning 3 months prior to surgery date
* Allergy to local anesthetics or NSAIDS
* Respiratory pathologies including:
* CPAP- non-compliant / untreated obstructive sleep apnea
* COPD
* Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)
* Contralateral diaphragm dysfunction
* BMI \> 40
* Ipsilateral extremity pre-existing nerve injury
* GFR \< 60
* NSAID contraindications
* Inability to follow up
* Revision surgery
* Patients requesting block as primary (avoidance of general anesthesia)
* Need or request for brachial plexus catheter or liposomal bupivacaine
* Vulnerable populations (pregnancy, incarceration, etc)
* non-English speaking
Interventions
DRUG
Bupivacaine
Conditions
Rebound PainShoulder ArthroplastyInterscalene Block
Locations
UVA Health
Charlottesville, Virginia 22903
United States