Skip to main content
Back to Trials
NCT07146685PHASE4Recruiting

Effect of Local Anesthetic Concentration on Rebound Pain

University of Virginia

Start Date

5/13/2026

Completion Date

1/28/2029

Summary

Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Total shoulder replacement patients (anatomic and reverse) * Adult patients (greater than or equal to 18 years) * Any gender * Any race Exclusion Criteria: * \- Chronic Pain diagnoses including: * substance/opioid use disorder * complex regional pain syndromes * fibromyalgia * Daily persistent opioid use spanning 3 months prior to surgery date * Allergy to local anesthetics or NSAIDS * Respiratory pathologies including: * CPAP- non-compliant / untreated obstructive sleep apnea * COPD * Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc) * Contralateral diaphragm dysfunction * BMI \> 40 * Ipsilateral extremity pre-existing nerve injury * GFR \< 60 * NSAID contraindications * Inability to follow up * Revision surgery * Patients requesting block as primary (avoidance of general anesthesia) * Need or request for brachial plexus catheter or liposomal bupivacaine * Vulnerable populations (pregnancy, incarceration, etc) * non-English speaking

Interventions

DRUG

Bupivacaine

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Rebound PainShoulder ArthroplastyInterscalene Block

Locations

UVA Health

Charlottesville, Virginia 22903

United States