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NCT07158736NARecruiting

Genicular Nerve Block for Knee Pain in the ED

University of Pennsylvania

Start Date

8/6/2025

Completion Date

9/1/2026

Summary

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Atraumatic knee pain * \>17 years age * X-ray of the knee obtained in the ED * Initial pain score (numeric rating scale) 5-10 Exclusion Criteria: * Fracture or dislocation on x-ray * large knee joint effusion identified on x-ray * allergy or contraindication to local anesthetics * History of local anesthetic systemic toxicity after receiving local anesthetics * Pregnancy * Incarcerated * History of knee replacement of affected knee * Concern for septic joint * Overlying cellulitis * Hemodynamic instability * Altered mental status or inability to consent for procedure.

Interventions

PROCEDURE

Genicular nerve block with bupivacaine and corticosteroids

OTHER

Standard of Care

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Conditions

Knee Pain

Locations

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Pennsylvania Hospital

Philadelphia, Pennsylvania 19104

United States

Pennsylvania Presbyterian Medical Center

Philadelphia, Pennsylvania 19104

United States

HUP Cedar

Philadelphia, Pennsylvania 19143

United States