NCT07158853PHASE1Recruiting
Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
University of Minnesota
Start Date
2/4/2026
Completion Date
8/31/2027
Summary
The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Ability to provide consent and comply with study procedures
* Diagnostic and Statistical Manual of Mental Disorders criteria for OUD
* Undergoing medication treatment for OUD. Participants may have current comorbid drug use, but primary diagnosis must be OUD
* Intention to remain in the study until intervention completion.
Exclusion Criteria:
* Any medical condition with neurological sequelae
* Head injury resulting in skull fracture or loss of consciousness of \>30 minutes
* Any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia)
* Any psychotic disorder (participants with other treated and stable psychiatric disorders will be included)
* Presence of a condition that would render study measures impossible to administer or interpret
* Age younger than 18
* Primary current substance use disorder on a substance other than opioids except for caffeine or nicotine
* In treatment instead of jail
* Pregnancy
* Disrespectful behavior towards the investigators and staff.
Interventions
DEVICE
Transcranial Direct Current Stimulation (tDCS)
Conditions
Opioid Use Disorder
Locations
University of Minnesota
Minneapolis, Minnesota 55455
United States