NCT07164131PHASE4Recruiting
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
Mayo Clinic
Start Date
9/15/2025
Completion Date
9/1/2031
Summary
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
• All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.
Exclusion Criteria:
* High clinical suspicion for Legionella pneumonia
* Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
* Antibiotics not for CAP
* Pregnant women (based on clinical assessment as part of standard of care)
* Severe CAP as defined by the ATS/IDSA criteria
* Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women)
* Receiving a different antibiotic (e.g quinolones)
* Admission \> 24 hours
* Known to be a prisoner
Interventions
DRUG
Doxycycline
DRUG
Azithromycin
Conditions
Community-acquired Pneumonia
Locations
Mayo Clinic in Arizona
Scottsdale, Arizona 85259
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224
United States
Mayo Clinic Health System-Mankato
Mankato, Minnesota 56001
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Mayo Clinic Health System-La Crosse
La Crosse, Wisconsin 54601
United States