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NCT07164131PHASE4Recruiting

Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Mayo Clinic

Start Date

9/15/2025

Completion Date

9/1/2031

Summary

The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission. Exclusion Criteria: * High clinical suspicion for Legionella pneumonia * Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice) * Antibiotics not for CAP * Pregnant women (based on clinical assessment as part of standard of care) * Severe CAP as defined by the ATS/IDSA criteria * Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women) * Receiving a different antibiotic (e.g quinolones) * Admission \> 24 hours * Known to be a prisoner

Interventions

DRUG

Doxycycline

DRUG

Azithromycin

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Conditions

Community-acquired Pneumonia

Locations

Mayo Clinic in Arizona

Scottsdale, Arizona 85259

United States

Mayo Clinic in Florida

Jacksonville, Florida 32224

United States

Mayo Clinic Health System-Mankato

Mankato, Minnesota 56001

United States

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States

Mayo Clinic Health System-La Crosse

La Crosse, Wisconsin 54601

United States