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NCT07167225RecruitingAccepts Healthy Volunteers

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

Roswell Park Cancer Institute

Start Date

4/3/2025

Completion Date

10/1/2028

Summary

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Detailed Description

PRIMARY OBJECTIVE: I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.

Eligibility Criteria

Age Range: 18 years to 25 years

Inclusion Criteria: * Young adult (18-25 years old). * Ability to read and write in English. * Participants must fall into one of the following groups (based on self-report): * Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month. * Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products. * E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly. * No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit). * Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities. Exclusion Criteria: * Individuals under the age of 18 or over the age of 25. * Currently pregnant or breastfeeding (female participants). * Unwilling or unable to follow protocol requirements

Interventions

OTHER

Effectiveness of different recruitment approaches

OTHER

Choice of study completion locations

OTHER

Cannabis Engagement Assessment

OTHER

E-cigarette dependence Scale

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Conditions

Cigarette Smoking-Related CarcinomaE-Cig Use

Locations

Roswell Park Comprehensive Cancer Center

Buffalo, New York 14263

United States