Back to Trials
NCT07168915PHASE1RecruitingAccepts Healthy Volunteers

A Study of V118E in Healthy Participants (V118E-003)

Merck Sharp & Dohme LLC

Start Date

10/8/2025

Completion Date

7/6/2027

Summary

Researchers are looking for new vaccines to prevent illnesses caused by a type of bacteria called Streptococcus pneumoniae. There are many different types of Streptococcus pneumoniae bacteria, called serotypes. Vaccines contain small parts of certain serotypes. These parts will not cause an infection but help the body create antibodies (proteins) to fight the bacteria. PREVNAR 20™ is a vaccine given to help to prevent disease from Streptococcus pneumoniae bacteria. Researchers designed a new vaccine, V118E, to help prevent disease from Streptococcus pneumoniae bacteria. The goal of this study is to learn how safe V118 formulation E is in Healthy Adults and how well people tolerate it.

Eligibility Criteria

Age Range: 18 years to 49 years

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: \- Is in good health before randomization Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has a history of invasive pneumococcal disease or known history of other culture-positive pneumococcal disease within 3 years prior to receiving study vaccination * Has a history of clinically significant endocrine, gastrointestinal (GI), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases

Interventions

BIOLOGICAL

V118E

BIOLOGICAL

PREVNAR 20™

BIOLOGICAL

Saline

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Healthy

Locations

Velocity Clinical Research, Hallandale Beach ( Site 0003)

Hallandale, Florida 33009

United States

QPS-MRA, LLC-Early Phase ( Site 0002)

South Miami, Florida 33143

United States

Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0004)

Springfield, Missouri 65802

United States

University of Texas Medical Branch ( Site 0001)

Galveston, Texas 77555-1115

United States