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NCT07171359NARecruiting

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

Washington State University

Start Date

6/1/2027

Completion Date

10/1/2027

Summary

The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal symptoms; mental, physical, sleep, and cognitive health; engagement with therapy, etc.) in individuals with Opioid Use Disorder (OUD) and individuals with Alcohol Use Disorder (AUD). This project will be completed in partnership with Another Chance Rehab (Portland): Portland's top addiction treatment program offering evidence-based treatment programs for a range of substance use disorders. Another Chance Rehab will serve as the project site for this work.

Detailed Description

The investigators will conduct a prospective, randomized, controlled trial. To identify which TMS protocol is most efficacious, there will be three arms to this study. 1. Treatment as Usual (TAU): Participants complete their regularly scheduled therapy activities and receive no add-on TMS. They will answer the demographic survey and outcome measure surveys (listed in a later section). 2. TAU + 3-minute TMS: Participants complete TAU as described above, with one 3-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total). 3. TAU + 9-minute TMS: Participants complete TAU as described above, with one 9-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total).

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18+ years old * Enrolled in the Intensive Outpatient Program at Another Chance Drug \& Alcohol Rehab Center of Portland, Portland, OR. * Diagnosed with Opioid Use Disorder * Diagnosed with Alcohol Use Disorder Exclusion Criteria: * Children \<18 years old * Pregnant * Non-English speaking * Currently taking prescription benzodiazepines or anti-convulsive medications * In active alcohol or opioid withdrawal * History of seizure disorder diagnosis * History of Schizophrenia, Bipolar Disorder, Mania

Interventions

DEVICE

TMS Low-Dose

DEVICE

TMS High-Dose

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Conditions

Alcohol Use DisorderOpioid Use Disorder

Locations

Another Chance Drug & Alcohol Rehab Center of Portland

Portland, Oregon 97232

United States