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NCT07174440NARecruiting

Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block

University Hospitals Cleveland Medical Center

Start Date

9/15/2025

Completion Date

1/25/2027

Summary

As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.

Eligibility Criteria

Age Range: 21 years to 75 years

Inclusion Criteria: * Age range: Adult patients 21-75 years of age * ASA status: I-III * Planned lumbar spine fusion involving no more than three levels * Ability to ambulate prior to surgery Exclusion Criteria: * Previous lumbar spine surgery * Metastatic cancer with involvement of the lumbar spine * eGFR \< 60 mL/min/1.73m2 * Active liver disease (hepatitis or cirrhosis) * Confirmed allergy to ropivacaine, dexmedetomidine or iohexol * Cognitive impairment resulting in inability to rate pain scores * Patients receiving 30 mg or more of morphine equivalent daily dosing preoperatively * Pregnancy

Interventions

DRUG

Ropivacaine (Epidural analgesia)

DRUG

Dexmedetomidine

DRUG

Iohexol

PROCEDURE

QST Procedure

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Conditions

Pain

Locations

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106

United States