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NCT07178509RecruitingAccepts Healthy Volunteers

A Study of SCAD Using Stress Contrast Echocardiography

Mayo Clinic

Start Date

11/25/2025

Completion Date

9/1/2027

Summary

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult \>18 years old * Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history Exclusion Criteria: * Unable to give consent * Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine. * Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®. * Pregnant. * Unable to interrupt breastfeeding. * Within 3 months of a heart attack. * Severe aortic stenosis. * Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).

Interventions

PROCEDURE

Stress Echocardiography with Contrast

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Conditions

Spontaneous Coronary Artery Dissection

Locations

Mayo Clinic

Rochester, Minnesota 55905

United States