NCT07178509RecruitingAccepts Healthy Volunteers
A Study of SCAD Using Stress Contrast Echocardiography
Mayo Clinic
Start Date
11/25/2025
Completion Date
9/1/2027
Summary
This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Adult \>18 years old
* Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history
Exclusion Criteria:
* Unable to give consent
* Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
* Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
* Pregnant.
* Unable to interrupt breastfeeding.
* Within 3 months of a heart attack.
* Severe aortic stenosis.
* Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).
Interventions
PROCEDURE
Stress Echocardiography with Contrast
Conditions
Spontaneous Coronary Artery Dissection
Locations
Mayo Clinic
Rochester, Minnesota 55905
United States