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NCT07182240NARecruiting

Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas

Roswell Park Cancer Institute

Start Date

12/22/2025

Completion Date

6/22/2027

Summary

To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing removal of cutaneous basal cell carcinomas (BCC).

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age ≥ 18 years * Participant must understand the investigational nature of this study and provide written consent prior to receiving any study-related procedure. * Participant must be clinically eligible for Mohs surgery as determined by their referring dermatologist and the Mohs surgeon. * The participant must have a BCC with superficial histology or a BCC with multiple histological features that also include superficial histology, which is appropriate for Mohs surgery. Exclusion Criteria: * Known or reported allergy to mineral oil, the optical agent used during imaging. * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * . Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure. * Unwilling or unable to follow protocol requirements

Interventions

DEVICE

LC-OCT Imaging

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Conditions

Basal Cell Carcinoma

Locations

Roswell Park Comprehensive Cancer Center

Buffalo, New York 14263

United States